Methotrexate in Atherogenesis and Cholesterol Metabolism
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Methotrexate in Atherogenesis and Cholesterol Metabolism
Methotrexate is a disease-modifying antirheumatic drug commonly used to treat inflammatory conditions such as rheumatoid arthritis which itself is linked to increased cardiovascular risk. Treatments that target inflammation may also impact the cardiovascular system. While methotrexate improves cardiovascular risk, inhibition of the cyclooxygenase (COX)-2 enzyme promotes atherosclerosis. These o...
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ژورنال
عنوان ژورنال: Cholesterol
سال: 2011
ISSN: 2090-1283,2090-1291
DOI: 10.1155/2011/503028